| Safari Hunt (1986) | 36,852,193 | 136 |
| Safari Quest (2014) | 26 | 1 |
| Safari Zone (2021) | 12,092,495 | 1,259 |
| Safe House (2018) | 61,768,799 | 353 |
| The Safe Place (2023) | 2,621,665 | 371 |
| Safebuster (1988) | 0 | 0 |
| Safecracker (1997) | 177,121 | 97 |
| Safecracker: The Ultimate Puzzle Adventure (2006) | 803,317 | 67 |
| Safety Driving Simulator: Car (2016) | 27,278 | 15 |
| SaGa Emerald Beyond (2024) | 563,363 | 487 |
| SaGa Frontier (1997) | 22,134,713 | 11,610 |
| SaGa Frontier 2 (1999) | 7,399,840 | 3,256 |
| Saga of Sins (2023) | 353,508 | 481 |
| Saga of the North Wind (2016) | 3,478 | 1 |
| Saga: Rage of the Vikings (1998) | 69,549 | 86 |
| SaGa: Scarlet Grace (2016) | 5,754,183 | 3,732 |
| Sage 3D (2018) | 0 | 0 |
| Saghala: Heroes of the Last World (2023) | 2,275 | 7 |
| Sagres (2023) | 337,297 | 311 |
| Sahara's Underworld (2022) | 351 | 1 |
| Sai Combat (1986) | 5,798 | 16 |
| Saibara Rieko no Mahjong Hourouki (1995) | 0 | 0 |
| SaiIn Rhythm (2021) | 1,102 | 1 |
| Saiko No Sutoka (2020) | 176,485,245 | 7,760 |
| Sail Forth (2022) | 806,067 | 786 |
| Sailaway: The Sailing Simulator (2017) | 963,751 | 715 |
| Sailing Era (2023) | 2,775,439 | 761 |
| Sailor Moon (1993) | 159,248,330 | 13,183 |
| Sailor Moon Drops (2015) | 476,281 | 1,568 |
| Sailor Moon: La Luna Splende (2011) | 380,649 | 51 |
| Saimai Rd (2022) | 275 | 2 |
| Saimazoom (1984) | 4,314 | 12 |
| Saint and Greavsie (1989) | 1,290 | 10 |
| Saint Dragon (1989) | 233,671 | 299 |
| Saint Haven: Dragon Nest (2017) | 355 | 6 |
| Saint Kotar (2021) | 472,451 | 860 |
| Saint Kotar: The Yellow Mask (2020) | 134,628 | 219 |
| Saint Patricks Day Break (2021) | 1,198 | 17 |
| SAINT SEIYA COSMO FANTASY (2016) | 3,075,961 | 3,482 |
| Saint Seiya Omega: Ultimate Cosmo (2012) | 5,382,073 | 827 |
| Saint Seiya Paradise: Saikyou No Senshitachi (1992) | 127,386 | 359 |
| Saint Seiya: Brave Soldiers (2013) | 17,469,667 | 4,362 |
| Saint Seiya: Ougon Densetsu (1987) | 11,534,255 | 543 |
| Saint Seiya: Ougon Densetsu Kanketsu Hen (1988) | 1,507,337 | 358 |
| Saint Seiya: Sanctuary Battle (2011) | 11,765,109 | 2,200 |
| Saint Seiya: Soldiers' Soul (2015) | 71,657,869 | 33,206 |
| Saint Seiya: The Hades (2006) | 5,493,403 | 2,994 |
| Saint Seiya: The Sanctuary (2005) | 4,902,518 | 2,150 |
| Saint Seiya: Typing Ryu Sei Ken (2003) | 32,988 | 15 |
| Saint Slaughter X Days (2018) | 0 | 0 |
| Saint Sword (1991) | 203,548 | 153 |
| Saints of Virtue (1999) | 172,744 | 4 |
| Saints Row (2006) | 76,203,688 | 16,079 |
| Saints Row (2022) | 187,618,225 | 76,759 |
| Saints Row 2 (2008) | 206,836,836 | 45,927 |
| Saints Row Double Pack (2010) | 4,650 | 2 |
| Saints Row IV (2013) | 645,331,395 | 120,343 |
| Saints Row: The Third (2011) | 422,048,337 | 96,564 |
| Sairento VR (2018) | 5,852,789 | 1,697 |
| Saiyuki: Journey West (2001) | 387,780 | 1,111 |
| Saki - sakuseikan. (2023) | 0 | 0 |
| Saki Portable (2010) | 126,052 | 104 |
| Sakuna: Of Rice and Ruin (2020) | 67,368,959 | 34,281 |
| Sakura Agent (2017) | 131,825 | 102 |
| Sakura and Crit: The Mock Game (2018) | 28 | 1 |
| Sakura Angels (2015) | 3,759,781 | 695 |
| Sakura Beach (2015) | 928,714 | 416 |
| Sakura Beach 2 (2015) | 570,397 | 204 |
| Sakura Clicker (2015) | 2,646,145 | 319 |
| Sakura Dungeon (2016) | 3,562,478 | 759 |
| Sakura Fantasy (2015) | 5,629,202 | 488 |
| Sakura Hime (2021) | 24,861 | 19 |
| Sakura Hime 2 (2022) | 14,503 | 9 |
| Sakura Hime 3 (2022) | 2,633 | 6 |
| Sakura In Gameland (2021) | 1,282 | 2 |
