| 1. |  Let's Play With Brigands | 314,074 | Maniac Mansion (Amiga Version | Full Playthrough) | 1:47:36 |
| 2. | wc10k | 245,702 | Let's Play Maniac Mansion (Nes) Part 11 Conclusion | 9:55 |
| 3. | PushingUpRoses | 198,031 | Let's Play: Maniac Mansion [part 10] with Roo (GOOD ENDING) | 17:30 |
| 4. |  NRWBoy18 | 190,959 | Lets Play - Indiana Jones und der letzte Kreuzzug [Teil 1] | 10:04 |
| 5. | MrVenom1974 | 152,463 | Wählt das nächste Re-Let's Play | Ihr entscheidet ^_^ | 11:05 |
| 6. | Greg's RPG HeaveN | 93,612 | LET'S PLAY Sam & Max Hit the Road // KOMPLETT 💿 LucasArts durchgeknalltes Grafik-Adventure (Deutsch) | 4:07:31 |
| 7. | Anachon | 52,576 | Let's Play Indiana Jones und der letzte Kreuzzug (Deutsch) #03 - Donovans Auftrag | 20:35 |
| 8. | DoctorM-LP | 19,347 | Lets Play MMM X-mas Odysee Teil 2 [ DoctorM Weihnachtsspecial ] [ HD ] | 23:14 |
| 9. | NintendoComplete | 14,750 | Maniac Mansion (NES) Playthrough | 3:10:36 |
| 10. |  Day-Glo Buffalo | 13,667 | Let's Play Maniac Mansion Deluxe - Part 7 - Meteor Police FTW | 11:23 |
| 11. | michael_stout79 | 10,465 | MANIAC MANSION Nintendo (NES) 1990 Game Play (EPISODE 1,072) Let's Play | 32:36 |
| 12. | VerticalSandwich | 9,229 | Let's Play Maniac Mansion (Wendy, Bernard) - The Finale! | 13:15 |
| 13. | Slowflake | 6,999 | Let's Play The Room - Part 6 | 13:42 |
| 14. |  The Mexican Runner | 5,054 | 45/714 Maniac Mansion (Part 2/2) - NESMania | 6:06:32 |
| 15. | AringusOokami | 4,538 | Monkey Island 4 ♦ #14 ♦ Der Beweis ♦ Let's Play | 22:37 |
| 16. | DieWutbuerger | 4,338 | Let's Play Maniac Mansion #09 [Deutsch / German] together - Showdown mit dem Meteor - | 21:52 |
| 17. | Mettbaron | 3,872 | Let's Play Maniac Mansion [9] - Auf zum Atem! (Finale) | 5:01 |
| 18. | Scribe | 3,128 | Let's Play Maniac Mansion (FINALE) - Night of the Tentacle | 32:23 |
| 19. | blutrotwurst | 2,730 | Lets Play Maniac Mansion[Deutsch]: #27 Endlich geschaft! | 18:38 |
| 20. | Kenshin1913 | 2,609 | Let's Play Maniac Mansion: Finale | 20:17 |
| 21. | LordSmapy | 2,177 | Let's Play Maniac Mansion, Part 10 - Wendy And Michael | 48:06 |
| 22. | Nasentroll | 1,867 | Let's play "Caren and the Tangled Tentacles" - 001 Der Anfang | 16:31 |
| 23. | ultralavos | 1,643 | Let's Play Maniac Mansion: 9 - Of Hamsters and Tentacles | 15:07 |
| 24. | Saintz | 1,205 | Let's Play Maniac Mansion [#07] Das epische Finale | 15:00 |
| 25. |  TurianShepard | 1,019 | MAN EATING PLANT!! - MANIAC MANSION (BLIND) #9 | 21:22 |
| 26. |  Gaming Jay | 937 | Maniac Mansion (DOS) - Let's Play 1001 Games - Episode 287 | 1:08:35 |
| 27. | Darth Vera | 785 | Let's Play Indiana Jones und der letzte Kreuzzug - #02 Veneeeeziaaaaaaaaaa!! | 13:42 |
| 28. | Lords of the Green Leaf | 698 | Let's Play: JA Back in Action [BLIND] Part 25: Visiting Miguel, Heading to San Mona, Maniac Mansion | 36:46 |
| 29. | Masters of Unlocking | 695 | Let's Play Maniac Mansion NES Part 11 - FINALE A End to all things Purple | 8:37 |
| 30. | Sensei Starman | 694 | Sensei Starman Plays Meteor Mess - The Michael and Syd Playthrough | 1:36:11 |
| 31. | DarkEvil87's Longplays (She, Her) | 604 | Maniac Mansion - DarkEvil87's Longplays - Full Longplay (PC) | 1:25:51 |
| 32. |  P3arCZ | 541 | /CZ Let's Play\ Maniac Mansion Deluxe Part 3 (Final) - Meteorská policie | 23:34 |
| 33. | Rafinoff | 519 | Maniac Mansion - Part 8 [Finale?] | Playthrough | 16:06 |
| 34. | ZetaPlays | 517 | Maniac Mansion (NES) - 02 - Summoning Space Police 27 Times | 33:18 |
| 35. | Ultra Publications | 508 | Let's Play: Maniac Mansion (NES) - Episode 4: One Possible Ending! | 20:18 |
| 36. | Working As Intended | 496 | PLAYING WITH HIS PACKAGE: Let's Play Retro Games Part 323 (Maniac Mansion) | 23:06 |
| 37. | Retro Floppy | 467 | Maniac Mansion - Das Koop-Letsplay mit DoctorspielchenLP - Folge 15 [ENDE] | 23:47 |
| 38. | Wretch Plays | 407 | Let's Play Maniac Mansion - Part 2 | NES Wretch-rospective [Wretch Plays] | 36:05 |
| 39. | Marstead | 406 | ✔️️ Full Blind Playthrough (Maniac Mansion) | 4:01:25 |
| 40. | KIKI KLICKT - Let's Play point & click classic | 399 | BERLIN CONNECTION: Berliner Morgenpost Promo Spiel #4 ~ Gold Ede - Let's Play & Lösung [Deutsch] | 20:02 |
| 41. | TehloneGamer | 392 | Let's Play Maniac Mansion: Part 5 | 15:53 |
| 42. |  Spike Plays | 383 | Spike Plays #short Mira mamá sin manos - MANIAC MANSION | 0:12 |
| 43. | Rocket Baby Dolls LP | 363 | Let's Play: Maniac Mansion 01 | 15:45 |
| 44. | Ennos RetrogameTV | 316 | P.P. Hammer:Mit dem Presslufthammer bewaffnet(Lets Play/Amiga)[Deutsch] | 22:40 |
| 45. | Famicom Dojo LIVE! | 308 | Planning a Heist - Sean Plays Maniac Mansion (NES), Part 4 | 1:32:34 |
| 46. | CarobiWing | 295 | Let's Play: Maniac Mansion #09 - Showdown in Dr. Freds Labor & alternatives Ende | 30:47 |
| 47. | Consequences | 281 | Maniac Mansion Mania Green Tentacle Needs Bernards Help Once Again! | 14:15 |
| 48. | VTuber Zeromaster & Power Plays | 253 | Maniac Mansion (NES) #PowerPlays FINALE?: Purple Donut Meteor | 12:13 |
| 49. | Wayward Spiel | 248 | Let's Play Maniac Mansion - Part 8 (FINAL) | 1:05:20 |
| 50. |  Abandonware | 247 | Holiday games - C64 full playthrough | 11:47 |
| 51. |  Octotiggy | 245 | HAMSTER-FRIENDLY ZONE - Maniac Mansion (Amiga) - Livestream | 5:01:23 |
| 52. | Gerste LP | 233 | Stellar Mess Demo Playthrough/Walkthrough [german/deutsch] | 52:14 |
| 53. | Corganto | 225 | Lets Play Maniac Mansion Mania - S01E02 - Unruhen 1.2 | 10:00 |
| 54. |  BitQuest | 224 | Maniac Mansion Finale | 17:39 |
| 55. | Video Games 101 | 223 | Maniac Mansion Playthrough | 4K 60FPS | Video Games 101 | 1:01:10 |
| 56. | Chris Barylick | 221 | The Mistakes Were Made Dinocast - Episode 25: Maniac Mansion (Original) (Play Through) | 1:38:57 |
| 57. | VertigoTeaparty | 208 | Let's Play Maniac Mansion (Steam version) - Full game | 2:52:46 |
| 58. | Torque | 205 | [GER/ENG] Let's Play "THE PIXEL HAS YOU" (DISK 1) from Daniele Spadoni | 16:13 |
| 59. | 10 Minute Gamer | 203 | 10MG Plays Maniac Mansion on NES | 10:33 |
| 60. | RichCale | 202 | Maniac Mansion playthrough with commentary (3/3) | 27:38 |
| 61. | HeMakesMePlay | 190 | Let's Play Meteor Mess (Maniac Mansion Remake)! - HeMakesMePlay | 2:52:02 |
| 62. | Mossi | 188 | Neo Magazin The Game Royale [HD] #3 [FINALE] - Zack feddich - Let's Play | 22:42 |
| 63. | REDDF1VE | 159 | Let's Play a BIT! #008 "Maniac Mansion" für PC (deutsch) HD | 1:06:29 |
| 64. |  Old Gidro | 158 | Gidrolo plays Maniac Mansion | 15:58 |
| 65. | Janno daddelt... | 154 | Let's Play The Cave (3/3) - Und wieder ist er planlos | 23:09 |
| 66. | St. George's Games | 146 | Maniac Mansion: Chapter 2 - Don't Be A Tuna Head! | 1:01:15 |
| 67. | ToraGēmingu /トラゲーミング | 138 | Maniac Mansion Deluxe ☄️: Dr. Fred, seine Tentakel und ich! [Let's Play] #Einteiler | 1:42:37 |
| 68. | aznluvr7 | 137 | Let's Play Maniac Mansion In English! Part 5: End Game | 18:19 |
| 69. | Geeks and Nerds | 121 | Pablo Plays - Maniac Mansion US (Beta) (NES) | 14:54 |
| 70. | Whitney Plays | 121 | Whitney Plays Maniac Mansion (PC) for Extra Life 2021 (PART 03) (END) | 2:27:01 |
| 71. | Amigos Retro Gaming | 109 | Amigos Plays Maniac Mansion (Amiga) Full Playthrough | 2:20:47 |
| 72. |  Rob64 Gaming | 106 | Maniac Mansion - NES LetsPlay Deutsch | 9:02 |
| 73. | Retro Gaming Junction | 88 | Let's Play Maniac Mansion Fully | 1988 PC Enhanced Version | Horror Month | 2:23:49 |
| 74. | Rydo | 83 | 🌭The Cave #14 | 34:16 |
| 75. | SUBPARCADE | 82 | Just a couple of tuna heads beating Maniac Mansion | 1:08:12 |
| 76. | RetroDetect | 82 | Maniac Mansion NES Full Playthrough (Dave Wendy Michael) | 45:50 |
| 77. | SGTBaker | 74 | "Let's not fail and not know it this time!" 1st playthrough of Maniac Mansion! Let's Play! (Part 2) | 3:32:57 |
| 78. |  Vampirschi Gaming | 72 | The Ritual - Playthrough (a short 2D point & click adventure) | 7:20 |
| 79. | TbMzockt | 72 | Indiana Jones 3 #007 — Und täglich grüßt das Schloss Brunwald [Let's Play] | 14:56 |
| 80. | sckchui | 70 | Blackwell series playthrough #5: Medium, Apparently | 21:25 |
| 81. | LULZCREW | 69 | Back To The Future IV: The Multitasking Crystal - PART 3 - Playthrough | 32:33 |
| 82. | Tolle Letsplays | 66 | Lets play Indiana Jones & the last crusade - Bonus: Schloss Brunwald (FAIL!) [deutsch] | 52:10 |
| 83. | thomas blaszkiewicz | 61 | " WELCOME TO THOMAS RETRO GAMER Plays Maniac Mansion (nes classic) " | 3:56:02 |
| 84. | th_pion | 60 | Let's Play: The Cave p22: Final | 16:39 |
| 85. | Ken Innes IV | 59 | Beating Maniac Mansion (NES) with Bernard & Wendy, My Playthrough (7/27/2023) | 1:21:42 |
| 86. | Bastisvlogs | 57 | Lets Play \\ Maniac Mansion Mania \\ Episode 30 \\ Memories of Zak | 21:09 |
| 87. | Madhog Thy Master | 55 | MADPlay: "Sam & Max Hit The Road" [FULL PLAYTHROUGH] | 6:24:20 |
| 88. | Midstrighter | 54 | MANIAC MANSION 3/3 [ENDE] - Das überraschende Ende - Let's Play - [60FPS/Ger/HD] | 54:15 |
| 89. | TomBombaDeal | 52 | Him [01] Maniac Mansion alter! *LET'S PLAY* Deutsch/German | 20:54 |
| 90. | Funky G | 52 | Let's Play Maniac Mansion (BLIND) Part 5: FINALE | 1:01:05 |
| 91. | SuperBunnyBun | 49 | Maniac Mansion (NES) Lets-Play Episode 4 | 23:00 |
| 92. | Milquetoast Gaming | 49 | MANIAC MANSION Full-Playthrough | Halloween Special 2023 | 2:57:45 |
| 93. | RetroGameQuest | 46 | Quest #61: Maniac Mansion [NES] (Complete playthrough with Bernard) | 1:14:16 |
| 94. | SFO Arcade VODs | 39 | Let's Play MANIAC MANSION (For NES) -- No Talent Gaming HALLOWEEN | 2:10:10 |
| 95. | Binary Legends | 36 | Maniac Mansion Enhanced Play-through (Wendy - Contract) (Lucasfilm Games - 1989 - DREAMM) | 56:07 |
| 96. | Mister Tom Light | 36 | LP - Maniac Mansion PS4 - Part 4 (FINALE) - Michael's route | 43:15 |
| 97. | Video Game Attic | 33 | Maniac Mansion Playthrough (Wendy and Bernard) | 3:13:20 |
| 98. | Reliving Retro | 32 | I Can't Believe The Game Let's You Do THIS!! | Maniac Mansion Playthrough | 9:55 |
| 99. | Vauldemare | 31 | Let's Play Sam & Max Hit the Road Part-10 Faux Bigfoot (Finale 1/2) | 28:30 |
| 100. | Hawkzombie | 30 | HawkZombie Plays: The Melting Apartment | 21:09 |
