1. | Northernlion | 246,421,458 | The Binding of Isaac: Repentance! (Episode 290: Culpable) | 30:03 |
2. | H0llyLP | 32,536,851 | AFTERBIRTH+ #106 - Gold - Let's Play The Binding of Isaac: Afterbirth+ | 34:01 |
3. | YuB | 19,760,972 | POOP GANG | 14:50 |
4. | bisnap | 11,342,554 | Isaac to help me recover from surgery | 2:41:04 |
5. | Chilluminati | 6,887,839 | DOES IT COUNT? | The Binding of Isaac: AFTERBIRTH+ RACES Gameplay | Let's Play #5 | 25:34 |
6. | Hutts | 5,823,719 | HELP I have 2 dogs here | 5:51:59 |
7. | Fimlar | 4,043,809 | Český Let'sPlay The Binding of Isaac: Afterbirth + #33 | 11:03 |
8. | Markiplier | 3,478,826 | WHAT IS THAT!? | Binding of Isaac - Part 1 | 17:19 |
9. | OneyPlays | 2,845,983 | BEST OF *ALL* of Binding of Isaac Games | 42:07 |
10. | Wolverous | 2,811,197 | The Binding Of Isaac Forever #107 - Diese Plays sind einfach nur wild | 1:12:03 |
11. | wolvesatmydoor | 1,901,841 | TRINKET TOWN [179] Afterbirth+ Gameplay | The Binding Of Isaac Afterbirth+ Let's Play | 49:46 |
12. | SuperMega | 1,495,803 | SuperMega Plays BINDING OF ISAAC - EP 6: Starring Ryan’s Mom | 19:33 |
13. | Welsknight Gaming | 1,323,154 | Acceptable | The Binding of Isaac: Repentance - Ep. 194 | 33:54 |
14. | Arumba | 1,257,086 | Arumba Plays The Binding of Isaac Afterbirth 121 | 36:47 |
15. | Perrick | 892,289 | The Binding of Isaac Rebirth #160.1 | Holpriger Start | 22:06 |
16. | LuckyCalamity | 761,308 | - Let's Play FR - The Binding of Isaac REBIRTH #87 : Fausse Bonne Idée | 26:52 |
17. | Annoying Orange Gaming | 701,425 | Gaming Grape Plays - The Binding of Isaac Rebirth: GRAPE EXPECTATIONS! | 11:29 |
18. | Wels After Dark | 650,417 | The Binding of Isaac: Afterbirth+ | Ep. 458: Safety | 28:23 |
19. | Rogue Justice | 569,440 | Mépris - The Binding of Isaac Repentance #154 - Let's Play FR | 47:53 |
20. | Millbeeful | 560,496 | The Big Risk Plays | The Binding of Isaac: Repentance | #6 | 56:50 |
21. | Retromation | 550,167 | Binding of Isaac Vampire Survivors Mode! | Let's Play Isaac Survivors (Mod) | 55:49 |
22. | ViteC ► Play | 483,169 | РАНДОМНОЕ ПРИКЛЮЧЕНИЕ ► The Binding of Isaac: Afterbirth+ |87| AlphaBirth, Quarry mods | 54:23 |
23. | TheTurtleMelon | 458,771 | THE BEST HORSE EVER! - Part 6783 - Secret of the Magic Crystal | 27:28 |
24. | AccidentalGrenade | 409,438 | Isaac New Save File! The Binding of Isaac: Afterbirth Plus Episode 1 Let's Play! [Twitch VOD] | 3:32:17 |
25. | Sil | 405,259 | [LP] The binding of Isaac: Afterbirth+ Ужас на крыльях ночи | 25:44 |
26. | Stumpt | 394,884 | Stumpt Plays - The Binding of Isaac: Rebirth - #55 - Sanic Would Be Proud | 29:18 |
27. | Team Alpha | 374,680 | Alphabirth Item Guide: The Cosmos | 0:28 |
28. | Table | 345,565 | Table plays - "Gornax" or, Giant Enemy Crab | 23:47 |
29. | Olexa | 329,190 | ISAAC LEAD DEVELOPER KILBURN PLAYS MODDED CHARACTERS! | 1:14:19 |
30. | Flik's Gaming Stuff | 326,388 | Flik Plays The Binding of Isaac Afterbirth+ | #136 | "Greed Done" | 55:55 |
31. | OfficialNerdCubed | 308,933 | Nerd³ Plays... The Binding of Isaac - Afterbirth+ | 25:22 |
32. | lonniedos | 268,609 | WE'RE BREAKING UP. - The Binding of Isaac: Rebirth (iPhone Gameplay Video) | 5:55 |
33. | BaerTaffy | 254,086 | Baer Plays The Binding of Isaac: Repentance (Ep. 16) | 3:10:54 |
34. | Wanderbots | 246,571 | Curses, Foiled Again! - Let's Play The Binding Of Isaac: Repentance - Part 7 | 47:43 |
35. | Bruugar | 220,960 | The Binding of Isaac Afterbirth #47 - Apollyon, der Neue (Facecam Let's Play) | 40:38 |
36. | xQc | 220,820 | xQc Plays The Binding of Isaac: Afterbirth+ | xQcOW | 2:06:53 |
37. | Jelpe | 209,654 | The Binding of Isaac: Repentance - Osa 17 - Kaaos | 45:51 |
38. | Sinvicta | 207,281 | When #isaac plays nice?! - The Binding Of Isaac: Repentance #1034 #isaacrepentance #bindingofisaac | 1:12:59 |
39. | TheGamerMaldito | 205,470 | ¡TRES BEBÉS DE GOLPE PARA COMENZAR! - TBOI: AFTERBIRTH+ #286 | 1:01:26 |
40. | Der Nephias | 205,176 | THE BINDING OF ISAAC: AFTERBIRTH ★ #62 ★ Let's Play Afterbirth ★ german | 55:21 |
41. | TearofGrace | 199,554 | WITCHER 3/GERALT MOD (a whole new playstyle) | The Binding of Isaac: AFTERBIRTH PLUS | 12:02 |
42. | Rig VTuber | 195,452 | ¡LA CULPA ES DEL TIGRE! | Super Auto Pets | 16:51 |
43. | Forsen Plays | 181,352 | Forsen Plays The Binding of Isaac: Repentance - Part 22 (With Chat) | 1:05:47 |
44. | MFPallytime | 164,470 | ♥ The Binding of Isaac: Rebirth (Let's Play) #22 | 32:58 |
45. | Monsieur Rex | 164,172 | The Binding of Isaac : Afterbirth + † - Playthrough #02 [1080p HD] - No Commentary | 1:43:20 |
46. | Lazy Mattman | 156,667 | I Gulped EVERY Trinket in Isaac. It was a mistake. | 22:19 |
47. | Vargskelethor Uncut: Full Joel Streams | 149,687 | [Vinesauce] Joel - SculptGL Nintendo Horror | 1:33:10 |
48. | Zombey | 149,416 | Maggie, Maggie, Maggie! | #10 | Let's Play The Binding of Isaac: Rebirth | 48:28 |
49. | CohhCarnage | 146,922 | CohhCarnage Plays The Binding of Isaac: Repentance - Episode 49 | 37:26 |
50. | RageGamingVideos | 133,532 | ALPHABIRTH FUSING WITH REVELATIONS = AMAZING - Binding of Isaac: Afterbirth+ Mod! | 39:31 |
51. | SwitchForce | 127,291 | The Binding Of Isaac Switch Gameplay Let's Play | 25:26 |
52. | Rhapsody | 123,914 | Let's Play The Binding of Isaac Afterbirth+: Tried - Episode 53 | 53:50 |
53. | Serpent | 123,371 | Dora, NS en Marco Borsato - The Binding Of Isaac: Rebirth Playthrough #9 | 32:32 |
54. | GamesRadar | 123,190 | The best games on PlayStation Network (PSN) | 5:03 |
55. | MrAndersonLP | 122,076 | Let's Play The Binding of Isaac: Afterbirth Plus (The Forgotten Update) [Part 6] | 54:08 |
56. | AbeClancy | 120,885 | Two Esaus Are Better Than One - #345 - Abe Clancy Plays: The Binding of Isaac Repentance | 1:02:10 |
57. | Newfie Bangaa | 116,594 | Let's Play The Binding of Isaac: Afterbirth #80 - Hurrah [Final] | 44:57 |
58. | thereisnofuture | 116,181 | [128] Eden стрик на 4 цели | Help I'm stuck | The Binding of Isaac: Repentance | 40:54 |
59. | Luigikid Gaming | 107,757 | THE BINDING OF ISAAC: REBIRTH - ARE YOU SERIOUS, GOD?! | 24:14 |
60. | GlitcherHood | 106,547 | The Binding Of Isaac: Afterbirth + Let's Play ITA - Daily Challenge (10/08/17) | 32:51 |
61. | Mr Samuel Streamer | 103,097 | Keys, Bombs, and Hearts + Moving Channels! | Binding of Isaac: Repentance #4 | 34:43 |
62. | TheEmero | 99,491 | Let's Play The Binding of Isaac [s2e3] - Déjà vu | 49:58 |
63. | Kegy | 98,420 | Tschüss 2015 und Hallo 2016! | The Binding of Isaac Afterbirth | 44:10 |
64. | Super Beard Bros | 97,450 | The Binding of Isaac Rebirth | Let's Play Ep. 4: ft. Sunder | Super Beard Bros. | 14:19 |
65. | AppZialist | 97,113 | Dragons Aufstieg von Berk | Titan-Training als Ablenkungsmanöver! | [HD+] #1003 Let's Play | 18:49 |
66. | Psychedelic Eyeball | 96,352 | Let's Play Binding of Isaac Rebirth #17 - Antibirth | 42:23 |
67. | Necros | 92,595 | Horrortale Alphys - Доктор Франкенштейн | The Binding of Horrortale #6 | 1:27:37 |
68. | Jonus | 91,636 | RAINBOW BRIMSTONE | Lost Streaks: The Binding of Isaac: Afterbirth+ | 6 | 35:57 |
69. | xQc Gaming | 87,907 | XQC PLAYS THE BINDING OF ISAAC: REBIRTH WITH POKE #2 | 39:33 |
70. | IsaacGuru | 87,558 | Sculpted Pepper - The Binding of Isaac Fiend Folio | 6:38 |
71. | Shisheyu | 86,385 | #43 GULP BURGER - Isaac Repentance 0% TO DEADGOD 2023 | 2:41:32 |
72. | From Nowhere | 84,630 | OOH SIN ROBES - Northernlion Remix | 3:16 |
73. | Hutts 2 | 83,831 | Chat Helps Me DESTROY the Game - Hutts Streams Repentance | 1:28:09 |
74. | Eckyman | 83,733 | Let's Play Isaac: Afterbirth | 18 | Map | 33:37 |
75. | DeadPixel | 79,796 | Pack de EXPANSIÓN para AFTERBIRTH † (ALPHABIRTH MOD pack 1) | 11:01 |
76. | мр. Фрей | 74,480 | The Binding of Isaac: Afterbirth №1 стрим | 0:00 |
77. | Lyra_VT | 70,688 | Nin9tales Plays - The Binding of Isaac: Afterbirth + (11) | 44:04 |
78. | WoloU | 68,664 | Let's Play The Binding Of Isaac: Rebirth [Deutsch/60fps] - Part 15 - Einer dieser Runs.. | 22:11 |
79. | BrettUltimus | 68,241 | ALPHYS Ep 40 | The Binding of UNDERTALE Gameplay [Rebirth/Afterbirth Mod] | 21:16 |
80. | TimeToGrind | 66,494 | Doubling Enemies in Isaac is NOT THE PLAY | 0:22 |
81. | Boo | 65,542 | The Binding of Isaac | Let's Play #5 - Self-Harm | 56:28 |
82. | Gorbinski666 | 65,497 | The Binding of Isaac Repentance 3.0 ✿ 250 ✿ Let's Play German Deutsch | 45:13 |
83. | Dhiammara Gaming | 64,550 | LET'S TRY: ISAAC MODS | ALPHABIRTH NULL | 39:34 |
84. | Gar | 64,338 | The Binding of Isaac: Afterbirth (Commentary) #6: Waka Waka | 22:08 |
85. | PlayStation Europe | 63,991 | Circuit Breakers | SharePlay Set Up In 60 Seconds | PS4 | 1:31 |
86. | Dan Gheesling | 63,246 | RIDICULOUS ISAAC PALPATINE BUILD | 10:58 |
87. | Pedguin | 60,061 | Afterbirth Seed: Mage Playthrough | 32:26 |
88. | RockLeeSmile | 59,908 | Let's Play - The Binding of Isaac: Afterbirth [Daily 11/14/15] (Ep.10) (ft. AlpacaPatrol) | 26:31 |
89. | SidAlpha | 59,416 | Greenlight Developer scams bundle customers | 6:38 |
90. | Waffle Bros | 56,278 | ISAAC IS BAAAAACK! (for more HORROR!) | Let's Play The Binding of Isaac: Repentance | 32:02 |
91. | Rahmschnitzel | Let's Play | 56,102 | The Binding of Isaac: Rebirth #018 - Panzer, ich vernichte Sie! - Let's Play | 38:02 |
92. | Ren | 53,968 | REN'S AFTERBIRTH [042] Lilith | Let's Play The Binding of Isaac: Afterbirth ITA | 34:54 |
93. | Treufy | 52,597 | LE RETOUR DE TREUFY LE TUEUR DE TITANS ! [Shingeki no Kyojin | Let's Play FR] | 20:53 |
94. | Ace The Brave | 51,848 | #LetsPlayITA 🔴 The Binding of Isaac: Repentance #153 | 35:30 |
95. | Tomas2886Cz | 50,645 | ZPĚT A ZNAVEN [The Binding of Isaac: Antibirth] [CZ/SK Let's Play] | 31:16 |
96. | BroskiPlays! | 44,675 | Shops (Tips, Tricks & Strategies) - The Binding of Isaac: Repentance 101 Ep. 4 | 1:01:13 |
97. | Mr.Thomsn | 43,835 | The Binding of Isaac Afterbirth | Testing the New Char "Keeper" ⌈Let's Play⌋ | 20:09 |
98. | Blaster BrewMaster | 41,724 | GET DUNKED ON!!! | Sans plays Dark Souls + SMITE (Solo) | 1:40:39 |
99. | Phedran | 41,122 | The Binding of Isaac: Rebirth - 104 - Broken | 1:03:02 |
100. | Kate Lovelymomo | 39,403 | The Binding of Isaac Afterbirth+ with Surixplays [Episode 4] (Re-up) | 1:00:55 |