1. | The Game Theorists | Game Theory: Does Isaac DIE?!? Binding of Isaac Rebirth's Endings EXPLAINED. | 16,352,580 | |
2. | PewDiePie | MEME GAMES | PewDiePie | 8,328,559 | Walkthrough |
3. | Markiplier | BIGGEST RAGE OF MY LIFE!! | Give Up 2 | 5,862,525 | |
4. | EazySpeezy | Riddle School speedruns are incredibly clever | 5,734,816 | |
5. | zbing z. | [EP.1]The Binding of Isaac Afterbirth | ลูกกรอกผู้อาภัพ zbing z. | 5,031,187 | |
6. | elrubiusOMG | EL CERDO DICTADOR | Ultimate Chimera Hunt | 4,041,619 | |
7. | Rig Studio | El chisme de Duolingo, los memes y las interacciones en Twitter | 3,885,537 | |
8. | WIZZY | THE BINDING OF ISAAC: Toda la Historia Explicada [Flash a Repentance] | 3,585,465 | |
9. | Markiplier | WHAT IS THAT!? | Binding of Isaac - Part 1 | 3,478,826 | Let's Play |
10. | ShadowRekiga | The Binding Of Isaac: ALL 13 ENDINGS + INTRO, EPILOGUE, AND CREDITS | 3,474,238 | Vlog |
11. | CaptainSauce | RIDDLE SCHOOL IS A LIE? - Riddle School 4 + 5 Real Ending | 3,387,514 | |
12. | Rig Studio | INTENTARON TROLLEAR A OPERA GX *salió mal* | 3,358,316 | |
13. | TearofGrace | The Binding of Isaac REBIRTH: SOY MILK + QUAD SHOT + SCYTHES + CHOCOLATE MILK | 3,284,244 | |
14. | SSundee | The Binding of Isaac Rebirth | AFTERBIRTH HYPE!! | 3,073,349 | |
15. | CaptainSauce | NO MORE SCHOOL - Riddle Transfer 2 (Series Finale) | 3,002,293 | |
16. | ZackScottGames | The Binding of Isaac: Rebirth - Gameplay Walkthrough Part 1 - Isaac First Run (PC) | 2,869,539 | Walkthrough |
17. | Sharkness VS | RAP THE BINDING OF ISAAC ||| SHARKNESS | 2,830,565 | |
18. | Coisa de Nerd | CONTENTEM-SE COM POUCO! - Jogos da Galera (Parte 21) | 2,766,206 | |
19. | TearofGrace | The Binding of Isaac AFTERBIRTH: PENNY TEARS + MONSTRO'S LUNG + POLYPHEMUS | 2,720,055 | |
20. | Shammy | 2 dollars, 10 games. | 2,592,019 | |
21. | Northernlion | The Binding of Isaac: Rebirth - Let's Play - Episode 1 [Reborn] | 2,535,496 | Let's Play |
22. | EugeneSagaz | Босс: Сердце Мамы | Концовка 1 - The Binding of Isaac: Rebirth #4 | 2,449,533 | |
23. | Markiplier | SCHOOL'S BACK BABY! | Riddle Transfer - Part 1 | 2,406,616 | |
24. | TearofGrace | The Binding of Isaac AFTERBIRTH: BRIMSTONE + EPIC FETUS + BUTT BOMBS | 2,395,581 | |
25. | darvindarvinlol | The Binding of Isaac: Rebirth | All Endings + Credits | 2,259,180 | |
26. | 잠뜰 TV | 쁘오더 등장?! [아이작 리버스: 잠뜰 키우기 #1편] - The Binding of Isaac Rebirth - [잠뜰] | 2,259,045 | |
27. | TearofGrace | The Binding of Isaac AFTERBIRTH: LILITH + BFF + MAGIC MUSHROOM | 2,249,692 | |
28. | Trash | 6 ÉNIGMES FOLLES CACHÉES dans les JEUX VIDÉO | 2,216,013 | |
29. | Trash | 7 RÊVES FRÉQUENTS et leur SIGNIFICATION (ft. un Psy) | 2,211,564 | |
30. | Freddy Fazfuck | The Binding of Isaac: Antibirth OST Innocence Glitched (Basement) | 2,184,084 | |
31. | Video Game News | [The Binding Of Isaac: Rebirth] - Epilogue + All Endings | 2,143,471 | |
32. | DangerouslyFunny | This Game Is Free | 2,128,450 | |
33. | Markiplier | BIG ANGRY MOMMA | Binding of Isaac - Part 2 | 2,069,224 | |
34. | Hutts | One Shot FEST - Custom Afterbirth Challenge | 2,025,262 | |
35. | CaptainSauce | EVOLUTION HAS FAILED - Homo Evolution: Human Origins | 2,023,226 | |
36. | TearofGrace | The Binding of Isaac AFTERBIRTH: BRIMSTONE + MONSTRO'S LUNG + MOM'S KNIFE + BOUNCING TEARS | 2,020,078 | |
37. | Sinvicta | THE MOST POWERFUL RUN IN ISAAC - The Binding Of Isaac: Afterbirth+ #853 | 2,018,532 | |
38. | TearofGrace | The Binding of Isaac REBIRTH: IPECAC + QUAD SHOT + LOKI'S HORNS + ORBITING TEARS | 2,015,640 | |
39. | SSundee | The Binding of Isaac Afterbirth | POKEMON!! | 1,991,319 | |
40. | ViteC ► Play | ЛОМАТЬ, ТАК С КЛЮЧИКОМ! ► The Binding of Isaac: Repentance |10| Прохождение | 1,951,874 | |
41. | CaptainSauce | SAVE OUR FRIENDS - Riddle Transfer 1 | 1,936,153 | |
42. | TearofGrace | The Binding of Isaac AFTERBIRTH: HUSH VS TECH X + SPOON BENDER | 1,933,502 | |
43. | TearofGrace | The Binding of Isaac REBIRTH: BRIMSTONE + LUDOVICO + SPOON BENDER | 1,896,882 | |
44. | TearofGrace | The Binding of Isaac AFTERBIRTH: DR FETUS + TECH X + TECH 2 + BOUNCING TEARS | 1,892,407 | |
45. | TearofGrace | JACOB'S LADDER + SOY MILK + 16 SHOT + SPLASH DAMAGE | The Binding of Isaac: AFTERBIRTH PLUS Gameplay | 1,888,794 | |
46. | niko bellic | The Binding of Isaac Afterbirth+: Keeper Hardmode Speedrun (in 3:31) | 1,881,626 | |
47. | CoryxKenshin | MOM HOW COULD YOU!? | The Binding Of Isaac: Rebirth | 1,862,710 | |
48. | Oroboro | Best Run Ever | The Binding of Isaac: Rebirth | 1,858,174 | |
49. | TearofGrace | BEST BRIMSTONE BUILD EVER (Hydrophobicity Mod) | AFTERBIRTH PLUS Gameplay | 1,852,269 | |
50. | CaptainSauce | Evolving The Perfect Warrior - Blobfish Evolution | 1,849,693 | |
51. | EugeneSagaz | ЖЕРТВОПРИНОШЕНИЕ ЮДЖИКА | 1,833,522 | |
52. | CybeR | INNOCENCE GLITCHED [The Binding of Isaac animation] | 1,833,196 | |
53. | TearofGrace | The Binding of Isaac REBIRTH: BLUE BABY VS. MEGA SATAN | 1,832,635 | |
54. | TearofGrace | The Binding of Isaac REBIRTH: TRIPLE SHOT + SPLIT SHOT + GIANT TEARS | 1,830,040 | |
55. | EugeneSagaz | НЕВИННОЕ ДИТЯ - Прохождение The Binding of Isaac Rebirth #1 | 1,819,860 | |
56. | Ultrinik | The Binding Of Isaac Antibirth All Bosses Compilation (Officialized Fan DLC) | 1,812,252 | |
57. | Markiplier | JUST PLAIN UNLUCKY | Binding of Isaac: Afterbirth #1 | 1,809,082 | |
58. | Allaster | 200 Забегов в The Binding of Isaac: Repentance | 1,774,201 | |
59. | UberDanger | The Binding of Isaac Afterbirth+ review | 1,772,124 | Review |
60. | SlayXc2 | The CREEPIEST Isaac Boss EVER! Cacophobia (Fiend Folio) | 1,768,621 | |
61. | Rig Studio | DUOLINGO NO PUEDE SUPERAR A DUA LIPA | 1,764,276 | |
62. | zbing z. | [EP.3]The Binding of Isaac Afterbirth | ขาใหญ่บอสสุดโหด zbing z. | 1,748,083 | |
63. | HelldogMadness | ESPECIAL 1.000.000 DE SUSCRIPTORES! #UnMillonDeMadafakas Parte 1! | 1,748,036 | |
64. | YuB | UNLOCKING THE FORGOTTEN! (Binding Of Isaac) | 1,737,256 | Let's Play |
65. | TearofGrace | The Binding of Isaac REBIRTH: POLYPHEMUS + PROPTOSIS + BABYLON | 1,725,623 | |
66. | ElRichMC - Minecraft & Gaming a otro nivel | The Binding Of Isaac Afterbirth+ Ep79, LA RUN MÁS BESTIA DE TODO INTERNET [OP BR] | 1,717,114 | |
67. | chiciorPL | The Binding of Isaac: Afterbirth - TECHNOLOGY X + BRIMSTONE + GUPPY - SICK COMBOS Ep 47 | 1,714,836 | Vlog |
68. | 2 Left Thumbs | The FULL Binding of Isaac (w/ Repentance) & The Legend of Bum-Bo Story Explained | 1,713,879 | |
69. | Spookster | The Binding of Isaac: Repentance True Final Boss and Ending! | 1,699,380 | |
70. | zbing z. | [EP.2]The Binding of Isaac Afterbirth | ลูกกรอกตัวเมียกับพลังที่ยิ่งใหญ่ zbing z. | 1,696,439 | |
71. | mistermv | Best of MisterMV #08 ! | 1,690,889 | |
72. | chiciorPL | The Binding Of Isaac: Rebirth - MONSTRO'S LUNG + POLYPHEMUS + DT + THE PARASITE - Sick Combos Ep. 38 | 1,682,795 | |
73. | TearofGrace | TETRACHROMACY, MOST BEAUTIFUL & BROKEN MOD EVER | AFTERBIRTH PLUS Gameplay | 1,671,628 | |
74. | TearofGrace | The Binding of Isaac AFTERBIRTH: ULTRA GREED GOES BROKE | 1,644,876 | |
75. | TearofGrace | The Binding of Isaac REBIRTH: MONSTRO'S LUNG + CHOCOLATE MILK + SCYTHES | 1,627,365 | |
76. | Obsidian Time | РОГАЛИКИ - ЭТО МОЯ ЖИИИИИИИИИЗНЬ | 1,624,643 | |
77. | TearofGrace | The Binding of Isaac REBIRTH: IPECAC + TRIPLE SHOT + FIRE MIND = NAPALM | 1,622,308 | |
78. | TearofGrace | The Binding of Isaac REBIRTH: BRIMSTONE + MOM'S KNIFE + MOM'S EYE | 1,616,819 | |
79. | EugeneSagaz | Босс: Мама | Концовка: Эпилог - The Binding of Isaac: Rebirth #3 | 1,611,899 | |
80. | TearofGrace | DR. FETUS + CHOCOLATE SOY MILK + TECH X + SPLASH DAMAGE | The Binding of Isaac: Afterbirth Gameplay | 1,608,956 | |
81. | TearofGrace | THE MASKED MAN (Oculus Rift + Lodestone) | The Binding of Isaac: ANTIBIRTH Gameplay | 1,604,099 | |
82. | TearofGrace | The Binding of Isaac REBIRTH: ISAAC ROLLS OVER ??? | 1,601,781 | |
83. | Тиджой | Близнецы не такие сложные, как о них говорят — The Binding of Isaac: Repentance | 1,599,827 | |
84. | DangerouslyFunny | When You Do So Much Damage Bosses Die Almost Instantly in The Binding Of Isaac: Rebirth | 1,591,028 | |
85. | TearofGrace | The Binding of Isaac REBIRTH: BRIMSTONE + TRIPLE SHOT + BABYLON | 1,589,488 | |
86. | ViteC ► Play | Я ТЕПЕРЬ МЕГА САТАНА ► The Binding of BOSSES: Afterbirth |182| | 1,569,474 | |
87. | TearofGrace | The Binding of Isaac AFTERBIRTH: IPECAC + CHOCOLATE MILK + DOUBLE TRIPLE SHOT | 1,557,846 | |
88. | alexelcapo | LLEGÓ EL DÍA V2 - The Binding of Isaac Repentance - Directo 1 | 1,511,847 | |
89. | Leyendas & Videojuegos | La Historia de Isaac - L&V - The Binding of Isaac Afterbirth Plus | 1,505,258 | |
90. | TearofGrace | THE VOID + DELIRIUM'S ENDING | The Binding of Isaac: AFTERBIRTH+ Gameplay | 1,502,756 | |
91. | uidsea | The Binding of Isaac Afterbirth | A Few Mini Myths | Mythbusters | 1,491,009 | |
92. | RealGuyWhoIsReal | Real Tainted Lost Experience 3: The Marks, Man! | 1,488,862 | |
93. | TearofGrace | CONTROLLED TRIPLE BRIMSTONE VS THE WITNESS | The Binding of Isaac: ANTIBIRTH Gameplay | 1,485,895 | |
94. | Hutts | THE WORST ISAAC MODS 8 | 1,480,035 | |
95. | YuB | EPIC RUN AS THE FORGOTTEN! (Binding Of Isaac) | 1,473,060 | Let's Play |
96. | Rig Studio | LAS MEJORES RESPUESTAS DE INTERNET | 1,454,985 | |
97. | mistermv | PRESSION ARTÉRIELLE ! | BEST OF MISTERMV #12 | 1,451,102 | |
98. | TearofGrace | BOUNCE (Soy Milk + Double Triple Rubber Scythes) | The Binding of Isaac: Afterbirth Gameplay | 1,426,214 | |
99. | Hutts | I Heard You Like Damage... - Custom Afterbirth Challenge | 1,418,762 | |
100. | Allaster | 100 Забегов в The Binding of Isaac: Afterbirth/Afterbirth+ | 1,412,881 | |