| SYNTHETIK 2 (2021) | 736,282 | 1,043 |
| SYNTHETIK: Arena (2019) | 62,623 | 89 |
| Synthetik: Legion Rising (2018) | 1,825,881 | 1,055 |
| Synthwaifu: Neon Space Fighter (2021) | 0 | 0 |
| Synthwave Racers (2023) | 2,668 | 22 |
| Syobon Action (2007) | 775,089,929 | 10,357 |
| Syphon Filter (1999) | 18,241,377 | 10,387 |
| Syphon Filter 2 (2000) | 8,314,226 | 5,958 |
| Syphon Filter 3 (2001) | 4,635,365 | 3,685 |
| Syphon Filter: Combat Ops (2007) | 52,949 | 23 |
| Syphon Filter: Dark Mirror (2006) | 4,704,637 | 1,821 |
| Syphon Filter: Logan's Shadow (2004) | 8 | 1 |
| Syphon Filter: Logan's Shadow (2007) | 3,109,587 | 1,378 |
| Syphon Filter: The Omega Strain (2004) | 1,770,950 | 1,116 |
| SYREN (2017) | 272,232 | 133 |
| Syren and Friends Roast the Dev (2022) | 0 | 0 |
| Syrian Warfare (2017) | 3,641,737 | 982 |
| Syrup and the Ultimate Sweet (2015) | 1,034,390 | 472 |
| System 15000 (1984) | 1,015 | 1 |
| System Crash (2016) | 1,054,853 | 132 |
| System Critical 2 (2023) | 16,093 | 55 |
| System Flaw (2009) | 20,563 | 24 |
| System Invaders (2020) | 653 | 23 |
| System Protocol One (2010) | 1,270 | 19 |
| System Purge (2022) | 12,696 | 70 |
| System Rush (2005) | 18,266 | 25 |
| System Shock (1994) | 21,874,230 | 6,028 |
| System Shock (2022) | 571,660 | 448 |
| System Shock 2 (1999) | 27,610,256 | 10,795 |
| System Under Surveillance (2022) | 569 | 8 |
| System's Twilight (1994) | 1,057 | 9 |
| Systematic Immunity (2016) | 104,721 | 13 |
| Syvalion (1988) | 364,634 | 216 |
