| 4 Seasons Girls (2022) | 0 | 0 |
| 4 Soccer Simulators (1988) | 6,342 | 29 |
| 4 Travellers: Play French (2010) | 27 | 1 |
| 4 Travellers: Play Spanish (2010) | 0 | 0 |
| 4 Wheel Thunder (2000) | 76,991 | 177 |
| 4-D Warriors (1985) | 10,643 | 82 |
| 4-Player Bowling Alley (1979) | 5,098 | 12 |
| 40 Winks (1999) | 2,039,871 | 1,069 |
| 404Sight (2015) | 123,701 | 117 |
| 41 Hours (2021) | 122,551 | 320 |
| 428: Shibuya Scramble (2008) | 3,475,929 | 6,785 |
| 44 Minutes in Nightmare (2021) | 4,701,593 | 406 |
| 47 HEROINES (2019) | 99,042 | 27 |
| 4D Prince of Persia (1994) | 108,693 | 18 |
| 4D Sports Boxing (1991) | 107,990 | 119 |
| 4D Sports Tennis (1990) | 9,163 | 22 |
| 4DSnake (2019) | 44 | 3 |
| 4P Ping-Pong (2012) | 335 | 2 |
| 4Prot (2021) | 0 | 0 |
| 4Sight (2019) | 31,724 | 8 |
| The 4th Coming (1999) | 36,006 | 60 |
| 4th Generation Warfare (2022) | 187,399 | 97 |
| 4th Super Robot Wars (1995) | 5,828,709 | 3,745 |
| 4x4 Evo (2000) | 331,400 | 356 |
| 4x4 Evo 2 (2001) | 692,682 | 533 |
| 4x4 Hummer (2009) | 1,638,858 | 74 |
| 4x4 Off-Road Racing (1987) | 340,147 | 169 |
| 5 A Day Adventures (1993) | 500 | 5 |
| 5 Days a Stranger (2003) | 2,818,960 | 509 |
| 5 in 1 Solitaire (2010) | 2,201 | 19 |
| 5 Spots (2003) | 10,837 | 45 |
| 5 Spots II (2003) | 8,416 | 5 |
| 5 Spots Party (2009) | 19,928 | 17 |
| 5 Star Fishy (2026) | 0 | 0 |
| 5 Star Miami Resort (2019) | 8,900 | 11 |
| 5 Star Rio Resort (2017) | 10,505 | 23 |
| 5-in-1 Arcade Hits (2010) | 18,804 | 21 |
| 5-Letter-Kruiswoord (1990) | 163 | 1 |
| 50 Cent: Blood on the Sand (2009) | 17,478,632 | 1,817 |
| 50 Cent: Bulletproof (2005) | 12,850,491 | 1,533 |
| 50 Classic Games (2009) | 20,393 | 42 |
| 50 Mission Crush (1984) | 15,422 | 55 |
| 500 cc Grand Prix (1986) | 306,268 | 38 |
| 505 Tangram (2011) | 655 | 2 |
| 51:22:51 (2023) | 394 | 3 |
| 5D Chess with Multiverse Time Travel (2020) | 10,526,840 | 857 |
| 5th Fleet (1994) | 5,847 | 12 |
| 5th Gear (1988) | 185,520 | 73 |
| 6 Feet Behind (2021) | 54 | 4 |
| 6 Inch My Darling (1998) | 33,609 | 16 |
| 6 Seasons and a Game (2021) | 37,247 | 54 |
| 6-in-1 IQ Scale Bundle (2018) | 403,625 | 197 |
| 6-Pak (1995) | 78,181 | 100 |
| 60 Parsecs! (2018) | 127,232,485 | 3,934 |
| 60 Seconds! (2015) | 935,768,177 | 10,620 |
| 60 Seconds! Reatomized (2019) | 278,096,333 | 6,652 |
| 6180 the moon (2014) | 73,416 | 141 |
| 64 de Hakken!! Tamagotchi: Minna de Tamagotchi World (1997) | 452,351 | 243 |
| 64 Hanafuda: Tenshi no Yakusoku (1999) | 72,199 | 29 |
| 64 Trump Collection: Alice no Waku Waku Trump World (1998) | 3,965 | 9 |
| 64.0 (2017) | 2,746,137 | 702 |
| 64th Street: A Detective Story (1991) | 413,270 | 753 |
| 688 Attack Sub (1989) | 141,846 | 111 |
| 69 Summon Succubus (2022) | 0 | 0 |
| 7 Billion Humans (2018) | 6,414,903 | 1,382 |
| 7 Blades (2000) | 156,393 | 253 |
| 7 Colors (1991) | 137,548 | 74 |
| 7 Days a Skeptic (2004) | 2,006,437 | 292 |
| 7 Days to Die (2013) | 2,452,405,682 | 883,254 |
| 7 Days To Save The World (2022) | 80 | 1 |
| 7 Dni a 7 noci (1994) | 1,763 | 1 |
| 7 Sins : Lost in Labyrinth (2023) | 55,038 | 38 |
| 7 Wonders 2 (2007) | 150,590 | 56 |
| 7 Wonders II (2008) | 82,286 | 51 |
| 7 Wonders of the Ancient World (2006) | 6,134,522 | 329 |
