| 1. |  jacksepticeye | YOU TRIGGERED MY TRAP CARD | Slay The Spire #1 | 3,701 | |
| 2. |  Markiplier | I'M GONNA KILL A BUILDING | 3,690 | |
| 3. | jacksepticeye | BOSS SLAYER | Slay The Spire #2 | 3,305 | |
| 4. |  Baitybait | El MEJOR juego de cartas - Slay the Spire | 2,193 | |
| 5. |  Solem Hearthstone | The Perfect Alternatives to Hearthstone | 1,409 | |
| 6. | RTGame | An Increasingly Stupid Session of Slay the Spire | 1,230 | |
| 7. |  Game Maker's Toolkit | How Synergies Make Slay the Spire Fun | 1,165 | |
| 8. |  tvgry | Jak poświęciłem 50 godzin, by zabić jednego bossa | 1,044 | |
| 9. | MagikarpUsedFly | I tried | 1,044 | |
| 10. | Northernlion | Slay the Spire - Northernlion Plays - Episode 1 | 966 | Let's Play |
| 11. | Frost Prime | The GREATEST Slay The Spire run EVER | 965 | |
| 12. | Northernlion | Northernlion Plays Slay the Spire's New Character - Episode 1: The Watcher | 953 | Let's Play |
| 13. | The Spiffing Brit | The Worlds Hardest Video Game Challenge - Is Actually Super Easy... | 901 | |
| 14. | Frost Prime | THE FASTEST SHIVS YOU'VE EVER SEEN!! | 891 | |
| 15. | Frost Prime | The infinite of your DREAMS!! | 802 | |
| 16. | IGN | Slay the Spire Developers React to 5 Minute Speedrun | 768 | |
| 17. | Frost Prime | Can You Beat Peglin With 0 Refreshes?! | 669 | |
| 18. | Northernlion | Northernlion Rates Every Ironclad Card in Slay the Spire! | 629 | |
| 19. | ingeniousclown Gaming | Slay the Spire "Clones" are getting RIDICULOUS! | 621 | |
| 20. |  메탈킴 | 슬레이 더 스파이어에 대한 심플한 영상 리뷰 | 메탈킴 | 612 | |
| 21. | Jorbs | "Grudges" in Slay the Spire - The Reddit Post That Was Too Controversial for Reddit. | 608 | |
| 22. |  iXBT games | Переходим на диету! Обзор Slay the Spire (iOS) | 603 | |
| 23. | Northernlion | Slay the Spire - Northernlion Plays - Episode 576 [One] | 588 | Let's Play |
| 24. | RedRiotRoss | How 2 Slay the Spire | 583 | |
| 25. | Mr. Fruit | MY NEW FAVORITE GAME! | Slay the Spire | 570 | |
| 26. | Friends Without Benefits | Dicey Dungeons: Slay the Spire but With Dice!! - EPISODE 1 - Friends Without Benefits | 565 | |
| 27. | HandOfUncut | Der beste Run meines Lebens | Slay the Spire | 556 | |
| 28. | MagikarpUsedFly | I'm still trying | 551 | |
| 29. | Firebat | Firebat Learns Slay the Spire! P1 Defect Run Ascension 2 | 535 | |
| 30. | Frost Prime | The Most Stressful Slay The Spire Run of All Time | 534 | |
| 31. | Frost Prime | Is this not the most satisfying card in Slay The Spire?! | 532 | |
| 32. | Woowakgood's Gaming Channel | 이거 하다가 밤샘 스팀평가 압도적 긍정 함부로 운빨 망겜이라 부를 수 없는 카드 게임 - 슬레이 더 스파이어 | 516 | |
| 33. | Northernlion | Slay the Spire - Northernlion Plays - Episode 3 | 511 | Let's Play |
| 34. | 2kliksphilip | I'm a NERD?? | 508 | |
| 35. | alexelcapo | EL MAESTRO DE LAS CARTAS - Slay the Spire - EP 1 | 493 | |
| 36. | Previously Recorded | Previously Recorded - Slay the Spire | 489 | |
| 37. | PietSmiet | Nur 1 Versuch in Slay the Spire | 488 | |
| 38. | Frost Prime | I ranked every Relic in Slay The Spire | 485 | |
| 39. | Jorbs | SLAY THE SPIRE 2 IS ANNOUNCED | 479 | |
| 40. | KiraTV | This Is The Greatest Game Advertisement. | 474 | |
| 41. | Eleven | Nie przepadam za karciankami ale ta gra jest MEGA | Slay The Spire #1 | 469 | |
| 42. | Northernlion | Let's Look At: Slay the Spire! | 467 | |
| 43. | Frost Prime | This Peglin Relic Is Just As BROKEN In Slay The Spire | 467 | |
| 44. | Frost Prime | Why this means so much to me | 461 | |
| 45. | darkjay | Slay the Spire Speedrun: Ironclad any% 4:30 | 460 | |
| 46. | ТАК ОСТРО! | Новый Fallout, скандал Star Wars Outlaws, конец Dead Space, анонс Slay the Spire 2. Игровые новости! | 459 | |
| 47. | Northernlion | Slay the Spire - Northernlion Plays - Episode 29 | 453 | Let's Play |
| 48. | Frost Prime | The PERFECT Ritual Dagger deck! | 453 | |
| 49. |  Shadran | Slay The Spire #18 - Čím víc Zahraješ, Tím víc Zabiješ | 448 | |
| 50. | Northernlion | The Northernlion Live Super Show! [January 25th, 2018] | 447 | |
| 51. | Northernlion | Slay the Spire - Northernlion Plays - Episode 568 [Good Stuff] | 443 | Let's Play |
| 52. | Frost Prime | What if you started with 8 Claws AGAIN?! | 440 | |
| 53. | Frost Prime | Slay The Spire but I don't fight anyone (literally) | 439 | |
| 54. | Frost Prime | You'll Never Believe How I Won The Hardest STS Challenge!! | 437 | |
| 55. | Frost Prime | I ranked every card for the Ironclad in Slay The Spire | 437 | |
| 56. | Nintendo of America | Slay the Spire - Announcement Trailer - Nintendo Switch | 435 | Preview |
| 57. | 침착맨 플러스 | Slay the Spire | 플레이타임 440시간의 주호민 고수 초대석 | 432 | |
| 58. | Frost Prime | It's Time To Talk [Good Talk] | 427 | |
| 59. | Adam Millard - The Architect of Games | What Makes a Great Deckbuilder? | 424 | |
| 60. | Northernlion | The Northernlion Live Super Show! [December 7th, 2017] | 412 | |
| 61. | Frost Prime | PEGLIN IS IN SLAY THE SPIRE!! | 411 | |
| 62. | Firebat | EASY Watcher Run P1 - Slay the Spire | 409 | |
| 63. |  Lice萊斯 | 有史以來最強組包《 烏克蘭慈善包 》➤近百款強檔遊戲，只要40鎂◆消費100%救助烏克蘭難民，還可自調捐助比例◆戰慄深邃、殺戮尖塔、Superhot、SupraLand、喋血復仇、巫師傳說超多強作 | 406 | |
| 64. | Northernlion | Slay the Spire - Northernlion Plays - Episode 2 | 397 | Let's Play |
| 65. |  iRaphahell | Aruncam o privire peste SLAY THE SPIRE ! | 396 | |
| 66. | ElRichMC - Minecraft & Gaming a otro nivel | ElRichMC juega Slay the Spire | 394 | |
| 67. |  Kripparrian | Slay the Spire & PvE Card Games | 392 | |
| 68. | Not Albino | You Just Activated My Meteor Strike | 391 | |
| 69. | Upper Echelon | Blowing Up a 150k SCAM | 389 | |
| 70. | Firebat | Firebat Learns Slay the Spire! P2 Defect Run Ascension 2 | 388 | |
| 71. | Northernlion | My First Slay the Spire Video in YEARS | 385 | |
| 72. | RiskyCB | 2 Card Slay the Spire Run - Consistent Turn 1 Infinite Combo | 378 | |
| 73. | Frost Prime | What if EVERY relic was Calling Bell?! | 359 | |
| 74. | Ryfek | POLSKA GUROM - Slay The Spire #74 | 357 | |
| 75. | Bob Lennon | PUISSANCE MAXIMALE !!! -Slay the Spire- Petit gameplay détente (avec Jehal & Bob Lennon) | 354 | |
| 76. | Jorbs | INSANE POWER INCREDIBLY FAST! (+ New YouTube Content?) | Ascension 20 Ironclad Run | Slay the Spire | 353 | |
| 77. | Northernlion | Slay the Spire - Northernlion Plays - Episode 30 | 348 | Let's Play |
| 78. | Eligorko | Сердце Шпиля [Slay The Spire #5] | 347 | |
| 79. | Frost Prime | I ranked every Silent card in Slay The Spire | 342 | |
| 80. | Northernlion | SNKRX meets Slay the Spire? (Just King) | 342 | |
| 81. | Frost Prime | I ranked every Watcher card in Slay The Spire | 340 | |
| 82. | Frost Prime | Do I Have The BEST Card In Slay The Spire?! | 333 | |
| 83. | Trump | KIDS, DON'T READ BOOKS! - The Silent Run #2 - Slay the Spire | 330 | |
| 84. | Not Albino | Slay the Spire - IronChad | 330 | |
| 85. | Verac | Slay the Spire Review | "VERAC SELLS OUT" Edition™ ($$$) | 329 | Review |
| 86. | Jorbs | so we broke the game... | Ascension 20 Silent Run | Slay the Spire | 328 | |
| 87. | not Otzdarva | We BROKE this card in the funniest way... | Slay the Spire | 328 | |
| 88. | Frost Prime | This deck ACTUALLY does it all!! Perfect deck?! | 327 | |
| 89. | ViteC ► Play | ШПИЛЬ БОГА РАНДОМА ► Slay The Spire |1| Прохождение | 327 | |
| 90. | Hutts | Isaac in Slay the Spire! (Completely Broken) | 323 | |
| 91. | alexelcapo | HASTA EL FINAL - Slay the Spire - EP 7 | 320 | |
| 92. | Frost Prime | What if you played as The Slime Boss?! | 319 | |
| 93. | Northernlion | Northernlion Attempts the Indie Pentathlon (01/26/2019) | 319 | |
| 94. | Trump | THIS GAME IS LIKE DUNGEON RUN - Trump's Tries: Slay the Spire #1 | 318 | |
| 95. | Frost Prime | What if EVERY Floor Was An Elite?! | 317 | |
| 96. | ShaunTheLegend | Synthetic Man Thinks Every Modern Game Is Woke Because He Can't Have A White Male Power Fantasy.... | 317 | |
| 97. | DangerouslyFunny | You Guys Made Me Do This | 314 | |
| 98. | Northernlion | Slay the Spire - Northernlion Plays - Episode 105 [Surely Not Another Strength Daily?] | 313 | Let's Play |
| 99. | Monark | ESCALANDO A ESPIRAL DA MORTE!!! - Slay The Spire | 312 | |
| 100. |  Rhapsody | Slay the Spire Draft Champions: On a Rampage - Episode 1 (ft. Olexa) | 308 | Let's Play |
